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Se adhiere a las uniones y la señalización celular mediada por beta-catenina en un organismo no metazoario

M J Grimson¹, J C Coates, J P Reynolds

¹Dept of Biological Sciences, Texas Tech University, Lubbock 79409, USA.

|December 29, 2000

Resumen

Las uniones de adherentes, cruciales para la organización de los tejidos animales, se encontraron en el organismo no animal Dictyostelium. Este descubrimiento revela que la beta-catenina es

Área de la Ciencia:

Biología celular Biología celular.
Biología evolutiva Biología evolutiva.
Biología del desarrollo Biología del desarrollo.

Sus antecedentes:

Las fuerzas mecánicas entre las células son vitales para la organización de los tejidos animales.
Las uniones de adherencias unen las células a través del citoesqueleto de actina, formando estructuras de tracción.
La beta-catenina, una proteína de unión de adherens, también regula la expresión génica.

Objetivo del estudio:

Para investigar los orígenes evolutivos de las uniones de adherens.
Para buscar las uniones de adherens fuera del reino animal (Metazoa).
Comprender la evolución temprana de las funciones duales de la beta-catenina.

Principales métodos:

Investigó el Dictyostelium discoideum no metazoario para las uniones intercelulares.
Los genes aislados y caracterizados que codifican las proteínas involucradas en estas uniones.
Examinó el papel de un homólogo de la beta-catenina en Dictyostelium.

Principales resultados:

Descubrió uniones intercelulares asociadas a la actina en el Dictyostelium.
Se identificó un homólogo de la beta-catenina de Dictyostelium, "aardvark", en estas uniones.
Aardvark es esencial tanto para la formación de complejos de unión como para la señalización celular.

Conclusiones:

Las uniones de adherens existen fuera del reino animal.
El doble papel de la beta-catenina en la adhesión celular y la señalización es anterior al origen de los Metazoa.
Este hallazgo proporciona información sobre la evolución temprana de la multicelularidad y la comunicación celular.

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