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El ADN-PKcs es necesario para la activación de la inmunidad innata por el ADN inmunostimulador

W Chu1, X Gong, Z Li

  • 1The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego 9500 Gilman Drive 92093, La Jolla, CA, USA. wmchu@ucsd.edu

Cell
|January 4, 2001
PubMed
Resumen

El ADN bacteriano y los oligodeoxirribonucleótidos inmunostimuladores sintéticos (ISS-ODN) activan la inmunidad innata. DNA-PKcs e IKKbeta son cruciales para esta respuesta de citoquinas, vinculando la reparación del ADN a la señalización inmune.

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