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Aumento del riesgo de accidente cerebrovascular en pacientes con el polimorfismo A12308G en las mitocondrias
Lancet (London, England)
|January 6, 2001
Resumen
Una variante genética específica, A12308G, en el gen mitocondrial tRNA ((Leu ((CUN)) aumenta significativamente el riesgo de accidente cerebrovascular en personas con la mutación A3243G que causa el síndrome MELAS. Este hallazgo ayuda a comprender los factores de riesgo de accidente cerebrovascular MELAS.
Área de la Ciencia:
- Genética La genética.
- Neurología Neurología.
- Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales Enfermedades mitocondriales
Sus antecedentes:
- La mutación A3243G en el ADN mitocondrial está relacionada con el síndrome MELAS (encefalomiopatía mitocondrial, acidosis láctica y accidente cerebrovascular).
- Los factores precisos que elevan el riesgo de accidente cerebrovascular en pacientes con MELAS siguen siendo incompletamente entendidos.
- Investigaciones anteriores indicaron que las mutaciones en el gen mitocondrial tRNA ((Leu ((CUN)) podrían modificar los efectos bioquímicos de la mutación A3243G en las células de cáncer de pulmón.
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