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Aumento de la actividad de la enzima convertidora de angiotensina en muestras de arterias coronarias de pacientes con
1Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan. hoshidas@orh.go.jp
Circulation
|February 7, 2001
Resumen
La actividad de la enzima vascular de conversión de la angiotensina (EAC) está elevada en las lesiones culpables del síndrome coronario agudo, lo que sugiere un papel en el desarrollo de la lesión coronaria activa. Esto contrasta con la enfermedad cardíaca isquémica estable y la restenosis, donde la actividad de la ECA no aumentó significativamente.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- La bioquímica es la bioquímica.
- Cardiología Intervencionista Cardiología intervencionista.
Sus antecedentes:
- Los inhibidores de la enzima de conversión de la angiotensina (ECA) son vitales para la prevención secundaria de la enfermedad isquémica del corazón.
- Sin embargo, los inhibidores de la ECA no previenen eficazmente la restenosis después de procedimientos coronarios.
- La actividad de la ECA vascular en las lesiones coronarias culpables sigue sin ser cuantificada.
Objetivo del estudio:
- Para cuantificar la actividad vascular de la ECA en las lesiones coronarias culpables.
- Investigar la relación entre la actividad de la ECA y el síndrome coronario agudo (SCA) frente a la enfermedad isquémica cardíaca estable (EISC) con y sin restenosis.
Principales métodos:
- El tejido vascular se obtuvo a través de aterectomía coronaria direccional.
- La actividad de la ECA se midió en pacientes con SCA (n=17) y DSI (n=36).
- Los pacientes con SIHD se estratificaron en grupos con y sin restenosis, incluida la restenosis en el stent y la restenosis no relacionada con el stent.
Principales resultados:
- La actividad de la ECA se incrementó significativamente en las lesiones culpables de los pacientes con SCA (0,87±0,12 nmol/min/mg de proteína; P<0,01).
- No se observó ninguna diferencia significativa en la actividad de la ECA en pacientes con EIS con restenosis (0.19±0.05) en comparación con aquellos sin restenosis (0.20±0.05).
- La actividad sérica de la ECA no difería significativamente entre los grupos de pacientes.
Conclusiones:
- El aumento de la actividad vascular de la ECA está presente en las lesiones culpables asociadas con el síndrome coronario agudo.
- Este hallazgo sugiere que el aumento de la actividad ACE contribuye a la patogénesis de lesiones coronarias activas.
- La actividad vascular de la ECA puede ser un objetivo para nuevas estrategias terapéuticas en el SCA.
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