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Cambios en la densidad mamaria asociados con el inicio, la interrupción y el uso continuo de la terapia de reemplazo
C M Rutter1, M T Mandelson, M B Laya
1Group Health Cooperative of Puget Sound, Center for Health Studies, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA. rutter.c@ghc.org
JAMA
|February 15, 2001
Resumen
El inicio de la terapia de reemplazo hormonal (TRH) aumenta la densidad mamaria, mientras que la interrupción la disminuye. Estos cambios dinámicos en la densidad mamaria están relacionados con el uso de TRH en mujeres posmenopáusicas.
Área de la Ciencia:
- Endocrinología Reproductiva y Reproducción.
- Oncología Oncología.
- Radiología Radiología.
Sus antecedentes:
- Se sabe que la terapia de reemplazo hormonal (TRH) aumenta la densidad mamaria.
- El aumento de la densidad mamaria se asocia con una disminución de la sensibilidad mamográfica.
- Faltan estudios sistemáticos sobre los efectos de la interrupción y continuación de la TRH en la densidad mamaria.
Objetivo del estudio:
- Investigar el impacto del inicio, la interrupción y la continuación de la TRH en la densidad mamaria.
- Para analizar los cambios en la densidad mamaria en mujeres posmenopáusicas sometidas a TRH.
- Proporcionar datos sobre la relación dinámica entre la TRH y la densidad mamaria.
Principales métodos:
- Un estudio de cohorte observacional en el que participaron 5212 mujeres posmenopáusicas.
- Datos recopilados a partir de mamografías de detección entre 1996 y 1998.
- La densidad mamaria se evaluó utilizando la escala BI-RADS, comparando a las usuarias de TRH (iniciadoras, discontinuadoras, continuadoras) con las no usuarias.
Principales resultados:
- El inicio de la TRH aumentó significativamente la densidad mamaria (RR, 2.57).
- La interrupción de la TRH se asoció con una disminución de la densidad mamaria (RR, 1.81).
- El uso continuo de TRH mostró un aumento de la densidad (RR, 1.33) y una alta densidad sostenida (RR, 1.45).
Conclusiones:
- Los cambios en la densidad mamaria relacionados con la TRH son dinámicos.
- El inicio de la TRH conduce a un aumento de la densidad mamaria.
- La interrupción de la TRH conduce a una disminución de la densidad mamaria.
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