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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Hacia un cuidado del cáncer basado en mecanismos
1Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. david_livingston@dfci.harvard.edu
JAMA
|February 15, 2001
Resumen
Los mecanismos moleculares del comportamiento de las células tumorales se han descubierto durante más de 25 años, transformando el diagnóstico, el pronóstico y el tratamiento del cáncer. El futuro cuidado y prevención del cáncer estará dominado por estos conocimientos moleculares y las nuevas tecnologías.
Área de la Ciencia:
- Oncología Oncología.
- Biología Molecular Biología Molecular
- Investigación de Investigación del Cáncer.
Sus antecedentes:
- Progreso significativo en la comprensión de los mecanismos moleculares de las células tumorales en los últimos 25 años.
- El conocimiento establecido ya ha influido en el diagnóstico actual del cáncer, el pronóstico y las estrategias de tratamiento.
Objetivo del estudio:
- Para resaltar el impacto de los mecanismos moleculares elucidados en el cuidado del cáncer.
- Proyectar el futuro dominio de los enfoques moleculares en la oncología.
Principales métodos:
- Revisión de 25 años de hallazgos de la investigación del cáncer.
- Análisis de la traducción de los descubrimientos de la ciencia básica a la práctica clínica.
Principales resultados:
- La comprensión detallada de los mecanismos moleculares ha llevado a la mejora de los métodos diagnósticos, pronósticos y terapéuticos.
- Las tecnologías emergentes están facilitando la aplicación de la ciencia básica en entornos clínicos.
Conclusiones:
- Los mecanismos moleculares son fundamentales para comprender y combatir el cáncer.
- El futuro cuidado y prevención del cáncer será cada vez más impulsado por conocimientos moleculares y avances tecnológicos.
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