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Quimerismo en niños con dermatomiositis juvenil
Lancet (London, England)
|February 24, 2001
Resumen
El quimerismo, la presencia de dos poblaciones celulares distintas, se encontró en la mayoría de los niños con dermatomiositis juvenil. Este hallazgo sugiere un posible vínculo entre el quimerismo y el trastorno autoinmune.
Área de la Ciencia:
- Reumatología Pediátrica.
- Inmunología Inmunología.
- Genética La genética.
Sus antecedentes:
- La dermatomiositis juvenil (DMJ) comparte similitudes clínicas con la enfermedad crónica de injerto contra huésped.
- El papel potencial del quimerismo en la patogénesis de la DMJ sigue siendo en gran medida inexplorado.
Objetivo del estudio:
- Para investigar la presencia y la extensión del quimerismo en niños diagnosticados con dermatomiositis juvenil.
Principales métodos:
- Se empleó la reacción en cadena de la polimerasa (PCR) para detectar el quimerismo.
- El análisis incluyó células mononucleares de sangre periférica y muestras de tejido muscular.
- Los grupos de comparación consistieron en hermanos y controles no afectados.
Principales resultados:
- El quimerismo se detectó en 13 de 15 niños con DMJ.
- Se identificaron células maternas en la sangre periférica de 11/15 pacientes con DMJ y en el tejido muscular de 12/15.
- Se observaron tasas significativamente más altas de quimeras en pacientes con DMJ en comparación con hermanos y controles (p<0.0001).
Conclusiones:
- Los hallazgos sugieren fuertemente una asociación significativa entre el quimerismo y la dermatomiositis juvenil.
- El quimerismo, particularmente el microquimerismo de las células maternas, puede ser un factor que contribuye al desarrollo o progresión de la DMJ.
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