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Las mutaciones en el gen del receptor cardíaco de la ryanodina (hRyR2) subyacen a la taquicardia ventricular
S G Priori1, C Napolitano, N Tiso
1Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy. spriori@fsm.it
Circulation
|February 24, 2001
Resumen
Las mutaciones en el gen receptor de ryanodina cardíaco humano (hRyR2) causan taquicardia ventricular polimórfica catecolaminérgica, un trastorno genético que conduce a arritmias inducidas por el estrés y muerte cardíaca súbita.
Área de la Ciencia:
- Genética cardiovascular Genética cardiovascular Genética cardiovascular Genética cardiovascular Genética cardiovascular
- Cardiología Molecular Cardiología Molecular
- La arritmogénesis es la arritmogénesis.
Sus antecedentes:
- La taquicardia ventricular polimórfica catecolaminergica (CPVT) es un trastorno genético que causa ritmos cardíacos peligrosos provocados por el estrés.
- Los patrones de ECG de la afección sugieren un vínculo con anormalidades de manejo de calcio intracelular.
- El gen receptor de la ryanodina cardíaca humana (hRyR2) fue investigado como una causa potencial.
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