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Clonogenic Assay: Adherent Cells
Published on: March 13, 2011
Los virus que inducen la proliferación en sistemas no permisivos como posibles causas de cánceres humanos
1Deutsches Krebsforschungzentrum, Heidelberg, Germany. zurhausen@dkfz-heidelberg.de
Lancet (London, England)
|February 24, 2001
Resumen
Los virus animales pueden transmitirse a los seres humanos, causando potencialmente tumores que aún no están relacionados con infecciones virales. Se recomienda una mayor evaluación de los tumores humanos para estos virus.
Área de la Ciencia:
- Virología Virología.
- Oncología Oncología.
- Epidemiología La epidemiología.
Sus antecedentes:
- Los virus animales, incluso aquellos que no se replican en las células humanas, representan un riesgo zoonótico potencial.
- Algunos virus humanos muestran potencial oncogénico en modelos animales.
- El manejo y la preparación de productos de origen animal pueden facilitar la transmisión del virus.
Objetivo del estudio:
- Para analizar el riesgo de adquirir infecciones por virus animales transmisibles a los seres humanos.
- Para investigar el vínculo potencial entre los virus animales y los tumores humanos.
- Proponer métodos para la detección de la nueva oncogénesis viral en cánceres humanos.
Principales métodos:
- Análisis de los informes epidemiológicos sobre la transmisión del virus de animales a humanos.
- Evaluación del potencial oncogénico viral en modelos animales.
- Evaluación de tumores humanos para virus que inducen la proliferación en sistemas no permisivos.
Principales resultados:
- Los virus animales podrían transmitirse a los seres humanos, causando potencialmente tumores.
- Los tumores humanos pueden estar vinculados a virus que actualmente no se les atribuyen.
- El potencial oncogénico de los virus en los animales sugiere la necesidad de vigilancia.
Conclusiones:
- Los tumores humanos deben ser sistemáticamente examinados para detectar nuevos agentes virales.
- Los sistemas de replicación no permisivos son cruciales para la detección de virus animales oncogénicos en muestras humanas.
- Comprender los riesgos virales zoonóticos es esencial para la salud pública y la investigación del cáncer.
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