Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Boundary Conditions: Lossless Lines01:21

Boundary Conditions: Lossless Lines

Consider a single-phase, two-wire, lossless transmission line terminated by an impedance at the receiving end and a source with Thevenin voltage and impedance at the sending end. The line, with length, has a surge impedance and wave velocity determined by the line's inductance and capacitance.
At the receiving end, the boundary condition states that the voltage equals the product of the receiving-end impedance and current. This relationship is expressed as a function of the incident and...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

Physical review letters·2024
Same author

Two risk assessments: Evaluating the use of indicator HF183 Bacteroides versus pathogen measurements for modelling recreational illness risks in an urban watershed.

Water research·2024
Same author

Acceleration and transport of relativistic electrons in the jets of the microquasar SS 433.

Science (New York, N.Y.)·2024
Same author

Academic clinician frontline-worker wellbeing and resilience during the COVID-19 pandemic experience: Were there gender differences?

Preventive medicine reports·2023
Same author

Factor structure of the Oxford Shoulder Score: secondary analyses of the UK FROST and PROFHER trial populations.

Journal of orthopaedic surgery and research·2023
Same author

Is it still a genuine occupational requirement to have a female only mammographic workforce in breast screening?

Radiography (London, England : 1995)·2023

Video Experimental Relacionado

Updated: Jun 29, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Complejos escabrosos con Notch para mediar en la formación de la frontera.

P A Powell1, C Wesley, S Spencer

  • 1Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Nature
|February 24, 2001
PubMed
Resumen

La proteína escabrosa estabiliza el receptor de Notch, agudizando los límites de los grupos proneurales. Este mecanismo asegura la formación correcta de neuronas pioneras individuales durante el desarrollo de la retina de Drosophila.

Más Videos Relacionados

In-Nucleus Hi-C in Drosophila Cells
11:58

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

A Neural Implant Design Toolbox for Nonhuman Primates
06:33

A Neural Implant Design Toolbox for Nonhuman Primates

Published on: February 9, 2024

Videos de Experimentos Relacionados

Last Updated: Jun 29, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

In-Nucleus Hi-C in Drosophila Cells
11:58

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

A Neural Implant Design Toolbox for Nonhuman Primates
06:33

A Neural Implant Design Toolbox for Nonhuman Primates

Published on: February 9, 2024

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • La neurociencia es la neurociencia.
  • Biología celular Biología celular.

Sus antecedentes:

  • La formación de patrones en el epitelio es poco conocida.
  • Los grupos proneurales, marcados por la expresión atonal, son elementos de patrón tempranos en el desarrollo de la retina de Drosophila.
  • La señalización de muescas es crucial para establecer y modelar la expresión atonal.

Objetivo del estudio:

  • Para investigar el papel de Scabrous en la señalización de Notch y la formación de grupos proneurales.
  • Para dilucidar los mecanismos moleculares subyacentes a la agudización de patrones en la retina de la Drosophila.

Principales métodos:

  • Se han realizado estudios in vivo en Drosophila melanogaster.
  • Pruebas bioquímicas para analizar las interacciones de las proteínas.
  • Análisis de la expresión atonal y los límites de los grupos proneurales.

Principales resultados:

  • La proteína secretada Scabrous se asocia con el receptor Notch.
  • Scabrous estabiliza la proteína Notch en la superficie celular.
  • Esta interacción conduce a agudizar los límites de los grupos proneurales.
  • Asegura el establecimiento de neuronas pioneras únicas.

Conclusiones:

  • La estabilización de la actividad de Notch mediada por escabrosidad es esencial para la formación de patrones precisos en la retina en desarrollo.
  • Los hallazgos proporcionan información sobre cómo los procesos de desarrollo establecen límites nítidos y destinos de una sola célula.