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Infecciones crónicas y el riesgo de aterosclerosis carotídea: resultados prospectivos de un estudio de gran población
1Departments of Neurology, University Clinic Innsbruck, Innsbruck, Austria.
Circulation
|February 27, 2001
Resumen
Las infecciones crónicas aumentan significativamente el riesgo de aterosclerosis, particularmente en personas sin factores de riesgo existentes. Esto sugiere que las infecciones juegan un papel clave en el desarrollo de la aterosclerosis a través de la inflamación.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Enfermedades infecciosas Enfermedades infecciosas.
- Epidemiología La epidemiología.
Sus antecedentes:
- Se debate el vínculo entre las infecciones crónicas y la patogénesis de la aterosclerosis.
- La evidencia epidemiológica sigue siendo controvertida.
Objetivo del estudio:
- Investigar la asociación entre las infecciones crónicas y el desarrollo de la aterosclerosis.
- Para evaluar el impacto de las infecciones crónicas en la progresión de la aterosclerosis carotídea.
Principales métodos:
- Encuesta prospectiva basada en la población (Estudio Bruneck) de 826 adultos de entre 40 y 79 años.
- Escaneo dúplex de alta resolución para evaluar la aterosclerosis carotídea durante 5 años.
- Criterios estándar de diagnóstico para identificar infecciones crónicas de las vías respiratorias, urinarias y dentales.
Principales resultados:
- Las infecciones crónicas amplificaron significativamente el riesgo de aterosclerosis (OR 4.08, P<0.0001), especialmente en aquellos sin aterosclerosis basal.
- Esta asociación fue válida para todas las infecciones bacterianas crónicas y se mantuvo significativa después de ajustar los factores de riesgo tradicionales.
- Los marcadores elevados de inflamación sistémica, endotoxina bacteriana y proteínas de choque térmico se relacionaron con un mayor riesgo de aterosclerosis en individuos infectados.
Conclusiones:
- Proporciona pruebas sólidas de que las infecciones crónicas contribuyen a la atherogénesis humana.
- La inflamación sistémica y la autoinmunidad son mecanismos potenciales que vinculan las infecciones con la aterosclerosis.
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