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1Department of Physiology and Biophysics, Program in Neuroscience, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA. acaicedo@chroma.med.miami.edu
Science (New York, N.Y.)
|February 27, 2001
Resumen
La mayoría de las células sensibles al amargo en ratas están estrechamente sintonizadas, respondiendo a un solo compuesto amargo. Esto sugiere que las distintas poblaciones celulares, no las amplias respuestas, subyacen a la percepción del sabor amargo.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Sensorial Biología Sensorial
- Fisiología celular del receptor del gusto Fisiología celular del receptor del gusto
Sus antecedentes:
- Investigaciones recientes indican que una sola célula de las papilas gustativas puede expresar múltiples receptores del sabor amargo.
- Este hallazgo ha reavivado el debate sobre si las células receptoras gustativas están selectivamente o ampliamente sintonizadas con los sabores amargos.
Objetivo del estudio:
- Para investigar las propiedades de sintonización de las células de los receptores gustativos de la rata.
- Para determinar si las células individuales pueden distinguir entre diferentes estímulos amargos.
Principales métodos:
- Las imágenes de calcio se utilizaron para medir las respuestas de las células receptoras del gusto de ratas.
- Las células fueron expuestas in situ a un panel de cinco compuestos amargos.
Principales resultados:
- La mayoría de las células gustativas sensibles a la amargura fueron activadas por solo uno de los cinco compuestos amargos probados.
- No se encontraron asociaciones significativas entre las respuestas a dos estímulos en células que reaccionaron a múltiples compuestos.
Conclusiones:
- La percepción del sabor amargo no depende de una población homogénea de células sensibles al amargo ampliamente sintonizadas.
- La evidencia sugiere que diferentes estímulos amargos activan distintas subpoblaciones de células gustativas sensibles al amargo.
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