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Inflamación y cáncer: de vuelta a Virchow?
1ICRF Translational Oncology Laboratory, St Bartholomew's and Royal London School of Medicine and Dentistry, UK. f.balkwill@icrf.icnet.uk
Lancet (London, England)
|March 7, 2001
Resumen
La progresión del cáncer comparte similitudes con la inflamación y la cicatrización de heridas. Dirigirse a las vías inflamatorias y a las citoquinas es prometedor para la prevención y el tratamiento del cáncer, ofreciendo nuevas estrategias terapéuticas.
Área de la Ciencia:
- Oncología Oncología.
- Inmunología Inmunología.
- Investigación de la inflamación Investigación de la inflamación.
Sus antecedentes:
- Los mecanismos de respuesta del cáncer se superponen con la inflamación y la cicatrización de heridas.
- Las células inflamatorias y las citoquinas dentro de los tumores pueden promover el crecimiento del cáncer y la supresión inmune.
- Las variaciones genéticas en los genes de citoquinas inflamatorias podrían influir en la susceptibilidad y gravedad del cáncer.
Objetivo del estudio:
- Para revisar los intrincados vínculos entre el cáncer y la inflamación.
- Discutir las implicaciones de estas conexiones para las estrategias de prevención y tratamiento del cáncer.
- Proporcionar una justificación para la orientación de las vías de citoquinas y quimioquinas en enfermedades malignas.
Principales métodos:
- Revisión de la literatura sobre la relación entre el cáncer, la inflamación y la cicatrización de heridas.
- Análisis del papel de las células inflamatorias y las citoquinas en la progresión tumoral.
- Examen de los polimorfismos genéticos en los genes de citoquinas inflamatorias.
- Revisión de las estrategias terapéuticas que involucran el bloqueo de citoquinas / quimioquinas y los medicamentos antiinflamatorios.
Principales resultados:
- Los mediadores inflamatorios en los tumores a menudo facilitan el crecimiento tumoral, la progresión y la inmunosupresión.
- La inhibición de las citoquinas inflamatorias ha demostrado su eficacia en la prevención del desarrollo experimental de cáncer.
- Los antagonistas de citoquinas y quimiocinas, al igual que los antagonistas del factor de necrosis tumoral, muestran eficacia clínica en enfermedades relacionadas.
Conclusiones:
- La inflamación puede actuar como un "combustible" para el desarrollo y la progresión del cáncer.
- Dirigirse a la red de citoquinas y quimioquinas a través del bloqueo es una estrategia viable para el tratamiento y la prevención del cáncer.
- Se justifica una mayor investigación sobre los medicamentos antiinflamatorios no esteroideos para la quimioprevención y el tratamiento de los cánceres.
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