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Bases estructurales para el intercambio de nucleótidos de guanina en Ran por el regulador de la condensación

L Renault1, J Kuhlmann, A Henkel

  • 1Max-Planck-Institut für Molekulare Physiologie, Postfach 50 02 47, 44202, Dortmund, Germany.

Cell
|May 5, 2001
PubMed
Resumen

El regulador de la condensación cromosómica (RCC1) actúa como un factor de intercambio de nucleótidos de guanina (GEF) para Ran. Una estructura cristalina revela cómo los iones sulfato estabilizan el complejo Ran-RCC1, crucial para el mecanismo de reacción del GEF.

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