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Paradójicamente aumentó la vasoconstricción mediada por el receptor de endotelina-B en monos viejos conscientes
1Cardiovascular Research Institute, University of Medicine, Dentistry of New Jersey, New Jersey Medical School, Newark, USA.
Circulation
|May 23, 2001
Resumen
El envejecimiento afecta las respuestas de vasoconstricción a la fenilefrina y la angiotensina II en monos. Sin embargo, la endotelina-1 (ET-1) causa una mayor vasoconstricción en monos viejos, lo que sugiere un deterioro de la vasodilatación dependiente del endotelio que involucra al receptor ET(B).
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Investigación sobre el envejecimiento Investigación sobre el envejecimiento.
- Farmacología Farmacología.
Sus antecedentes:
- Investigó el impacto del envejecimiento en las respuestas vasoconstrictoras en monos adultos viejos y jóvenes conscientes.
- Respuestas comparadas a la endotelina (ET), la fenilefrina (PE) y la angiotensina II (Ang II).
Objetivo del estudio:
- Para determinar cómo el envejecimiento afecta la respuesta del cuerpo a la endotelina (ET) y otros vasoconstrictores.
- Para dilucidar los mecanismos detrás de la sensibilidad vasoconstrictor alterada en primates envejecidos.
Principales métodos:
- Se utilizaron monos de Macaca fascicularis crónicamente instrumentados conscientes de edad avanzada (19,8+/-0,6 años) y adultos jóvenes (6,8+/-0,3 años).
- Vasoconstrictores administrados: PE, Ang II, endotelina-1 (ET-1), y un agonista del receptor ET(B (sarafotoxina S6c) con un antagonista del receptor ET(A) (BQ-123).
- Utilizó la inhibición de la sintasa de óxido nítrico (NOS) para evaluar el papel de la vasodilatación dependiente del endotelio.
Principales resultados:
- Reducción de la vasoconstricción a PE y Ang II en monos viejos en comparación con monos jóvenes.
- Significativamente mejoró la vasoconstricción a ET-1 en monos viejos.
- La vasoconstricción mediada por ET-1 a través del receptor ET ((B) también se mejoró en monos viejos.
- La inhibición de NOS normalizó la vasoconstricción mediada por ET-1 entre monos viejos y jóvenes, lo que indica una vasodilatación deteriorada dependiente del endotelio en individuos mayores.
Conclusiones:
- La vasoconstricción periférica a PE y Ang II disminuye con la edad.
- Paradójicamente, la vasoconstricción inducida por ET-1 se mejora en monos viejos.
- Esta mejora se atribuye al deterioro de la vasodilatación dependiente del endotelio, que probablemente involucra la vía del receptor ET (B).
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