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La proteína 6 relacionada con el receptor de LDL es un receptor de las proteínas Dickkopf

B Mao1, W Wu, Y Li

  • 1Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Nature
|May 18, 2001
PubMed
Resumen

Dickkopf1 (dkk1) se une a LRP6, un co-receptor de señalización de Wnt. Esta interacción inhibe la señalización Wnt/beta-catenina, revelando cómo las proteínas Dkk antagonizan la función del co-receptor Wnt durante el desarrollo embrionario.

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