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La elección impulsiva inducida en ratas por lesiones del núcleo accumbens del núcleo del núcleo
R N Cardinal1, D R Pennicott, C L Sugathapala
1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. rudolf.cardinal@pobox.com
Science (New York, N.Y.)
|May 26, 2001
Resumen
El núcleo selectivo acumulando lesiones del núcleo en ratas indujo persistentemente la elección impulsiva. Esto sugiere que la disfunción del núcleo accumbens es clave para la impulsividad, impactando en la adicción y los trastornos psiquiátricos.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Ciencias del comportamiento Ciencias del comportamiento.
Sus antecedentes:
- La elección impulsiva, que prefiere las pequeñas recompensas inmediatas a las grandes retrasadas, está relacionada con la adicción y los trastornos psiquiátricos.
- La base neuroanatómica subyacente de la elección impulsiva sigue siendo en gran medida indeterminada.
- Comprender los circuitos neuronales de la impulsividad es crucial para desarrollar tratamientos efectivos.
Objetivo del estudio:
- Para investigar las bases neuroanatómicas de la elección impulsiva.
- Determinar el papel del núcleo del núcleo accumbens en la regulación del comportamiento de elección impulsiva.
- Examinar la influencia de la corteza cingulada anterior y la corteza prefrontal medial en la elección impulsiva.
Principales métodos:
- Inducir lesiones selectivas en el núcleo accumbens del núcleo de las ratas.
- Evaluar el impacto de estas lesiones en el comportamiento de toma de decisiones, específicamente la elección impulsiva.
- Evaluación de los efectos de las lesiones en la corteza cingulada anterior y la corteza prefrontal medial sobre la elección impulsiva.
Principales resultados:
- Las lesiones selectivas del núcleo del núcleo accumbens llevaron a una elección impulsiva persistente en ratas.
- El daño a la corteza cingulada anterior no afectó el comportamiento de elección impulsiva.
- El daño a la corteza prefrontal medial no alteró la elección impulsiva.
Conclusiones:
- El núcleo del núcleo accumbens juega un papel crítico en los circuitos neuronales subyacentes a la elección impulsiva.
- La disfunción del núcleo accumbens puede ser un factor significativo en la neuropatología de la impulsividad.
- Estos hallazgos proporcionan un objetivo neuroanatómico para comprender y potencialmente tratar trastornos caracterizados por la impulsividad.
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