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Polimorfismo de un solo nucleótido en la región no traducida de la prohibitina 3' y susceptibilidad al cáncer de mama
Lancet (London, England)
|May 30, 2001
Resumen
Una variante del gen de la prohibitina (alélo T) está relacionada con un mayor riesgo de cáncer de mama, particularmente en mujeres más jóvenes con antecedentes familiares. La genotipización de la prohibitina puede ayudar en la evaluación temprana del riesgo de cáncer de mama para este grupo.
Área de la Ciencia:
- Genética La genética.
- Biología Molecular Biología Molecular
- Oncología Oncología.
Sus antecedentes:
- El ARN de la región 3' no traducida del gen de la prohibitina regula la progresión del ciclo celular inhibiendo la transición de fase G1 a S.
- Un alelo variante (alelo T) da como resultado un producto de prohibitina inactivo, lo que podría afectar el control de la proliferación celular.
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