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Progreso, remisión y regresión de las enfermedades renales crónicas

P Ruggenenti¹, A Schieppati, G Remuzzi

¹Clinical Research Centre for Rare Diseases Aldo e Cele Daccò, Ospedali Riuniti di Bergamo, 24125, Bergamo, Italy.

Lancet (London, England)

|May 30, 2001

Resumen

La enfermedad renal crónica (ERC) está aumentando a nivel mundial. La investigación muestra que un enfoque multimodal, que incluye el control de la presión arterial y la reducción de la proteinuria, puede retrasar la progresión y potencialmente reducir la necesidad de diálisis.

Área de la Ciencia:

Nefrología Nefrología.
Medicina interna es la medicina interna de las enfermedades.
Enfermedad renal Investigación de la investigación de la enfermedad renal.

Sus antecedentes:

La prevalencia de la enfermedad renal crónica (ERC) está aumentando en todo el mundo.
La mayoría de las ERC carecen de tratamientos específicos, lo que lleva a la enfermedad renal en etapa terminal.
Comprender los mecanismos de la enfermedad ofrece estrategias preventivas potenciales.

Objetivo del estudio:

Explorar estrategias renoprotectoras para el manejo de las nefropatías crónicas.
Investigar métodos para retrasar la progresión de la ERC y reducir la dependencia de la diálisis.
Para resaltar el potencial para la remisión de la enfermedad y la regresión del daño renal.

Principales métodos:

Revisión de los datos experimentales y clínicos sobre la progresión de la ERC.
Análisis de las medidas renoprotectoras, incluido el control farmacológico de la presión arterial.
Evaluación de la reducción de la proteinuria, la reducción de los lípidos, el cese del tabaquismo y el control glucémico.

Principales resultados:

Los protocolos de manejo multimodal pueden tener un impacto significativo en la progresión de la ERC.
Los tratamientos disponibles pueden posponer la necesidad de diálisis en muchos pacientes.
La evidencia sugiere que la diálisis reducida o eliminada puede ser alcanzable para algunos.

Conclusiones:

Un enfoque combinado para la renoprotección es crucial para el manejo de las enfermedades renales crónicas.
Las intervenciones específicas pueden retrasar la progresión de la enfermedad y mejorar los resultados de los pacientes.
El objetivo final es lograr la remisión de la enfermedad y minimizar la dependencia de la diálisis.

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