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La terapia de reemplazo de estrógenos mejora la regulación barorreflex del flujo de salida simpático vascular en
B E Hunt1, J A Taylor, J W Hamner
1Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. hunt@mail.hrca.harvard.edu
Circulation
|June 20, 2001
Resumen
La terapia de reemplazo de estrógenos en mujeres posmenopáusicas no alteró la presión arterial en reposo, pero aumentó la ganancia de barorreflejo simpático, lo que sugiere efectos reguladores cardiovasculares más allá de los simples cambios de presión.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Endocrinología Endocrinología.
- Salud de la Mujer Salud de la Mujer.
Sus antecedentes:
- La pérdida de estrógeno en la menopausia está relacionada con un mayor riesgo de enfermedad cardiovascular en las mujeres.
- Los mecanismos precisos, particularmente en lo que respecta a la regulación de la presión arterial, siguen sin estar claros.
- Los datos existentes sobre los efectos de los estrógenos en la presión arterial en mujeres mayores son inconsistentes.
Objetivo del estudio:
- Para investigar el impacto de la terapia de reemplazo de estrógeno a largo plazo en la presión arterial y la regulación del barorreflejo en mujeres posmenopáusicas.
- Para determinar si el estrógeno influye en la actividad del nervio simpático vascular y su papel regulador.
Principales métodos:
- Estudió a 11 mujeres posmenopáusicas sanas antes y después de 6 meses de administración de estrógenos.
- Medida de la presión arterial mediante auscultación y fotoletismografía.
- Se evaluó la actividad nerviosa simpática vascular y la ganancia de barorreflejo utilizando microneurografía e infusiones farmacológicas.
Principales resultados:
- La terapia con estrógenos no alteró significativamente la presión arterial sistólica en reposo ni el aumento del barorreflejo cardíaco-vagal.
- Se observó un aumento significativo en la ganancia de barorreflejo simpático vascular (P = 0,02).
Conclusiones:
- La terapia de reemplazo de estrógeno a largo plazo influye en la regulación cardiovascular.
- Estos efectos sobre el control autónomo pueden no ser evidentes en las mediciones de presión arterial en reposo.
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