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Calidad farmacopea de los medicamentos suministrados por las farmacias nigerianas
R B Taylor1, O Shakoor, R H Behrens
1School of Pharmacy, The Robert Gordon University, Schoolhill, AB10 1FR, Aberdeen, UK.
Lancet (London, England)
|June 27, 2001
Resumen
Casi la mitad de los medicamentos en las farmacias nigerianas no pasaron las pruebas de calidad, con niveles de ingredientes activos que varían ampliamente. La baja garantía de calidad de fabricación es la causa probable, lo que potencialmente conduce al fracaso terapéutico y la resistencia a los antimicrobianos.
Área de la Ciencia:
- Ciencias Farmacéuticas Ciencias Farmacéuticas
- Química Medicinal La Química Medicinal es un campo de estudio de la química medicinal.
- Salud Pública La salud pública.
Sus antecedentes:
- Los medicamentos de baja calidad representan una amenaza significativa en los países menos desarrollados debido a la falsificación, la descomposición y la mala fabricación.
- El contenido inadecuado de ingredientes activos en los productos farmacéuticos puede conducir a fracasos en el tratamiento y resistencia a los medicamentos.
Objetivo del estudio:
- Investigar la calidad de varios medicamentos disponibles en las farmacias minoristas nigerianas.
- Identificar las razones de la mala calidad de los medicamentos, incluido el contenido de ingredientes activos.
Principales métodos:
- Recolección aleatoria de 581 muestras de fármacos en 27 tipos de 35 farmacias en Lagos y Abuja, Nigeria.
- Análisis del contenido de drogas utilizando métodos cromatográficos validados.
- Comparación del contenido de fármaco analizado con los estándares establecidos de la farmacopea.
Principales resultados:
- El 48% (279 de 581) de las muestras de fármacos no cumplieron con los límites de la farmacopea para el contenido de ingredientes activos.
- Las variaciones incluyeron muestras sin ingrediente activo, así como aquellas con cantidades superiores o inferiores a los rangos aceptables.
- Las tasas de incumplimiento fueron consistentes en las diferentes categorías de drogas.
Conclusiones:
- La garantía de calidad inadecuada durante la fabricación farmacéutica es la principal causa identificada de medicamentos de calidad inferior.
- La prevalencia de medicamentos de baja calidad en los países menos desarrollados contribuye a la resistencia antimicrobiana mundial y al fracaso del tratamiento de las enfermedades infecciosas.
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