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Tratamiento de emergencia del coma hiperammonémico neonatal con hipotermia sistémica leve

A Whitelaw, S Bridges, A Leaf

Lancet (London, England)

|July 17, 2001

Resumen

La hipotermia terapéutica trató con éxito el coma hiperammonémico en un recién nacido con un defecto del ciclo de urea. El enfriamiento redujo la producción de amoníaco, permitiendo métodos no enzimáticos para eliminar la toxina, lo que lleva a la recuperación.

Área de la Ciencia:

La bioquímica es la bioquímica.
Medicina Neonatal La medicina neonatal es una especialidad de la medicina neonatal.
Trastornos metabólicos Los trastornos metabólicos son trastornos metabólicos que se producen en el cuerpo.

Sus antecedentes:

Los defectos del ciclo de la urea son trastornos genéticos que afectan la desintoxicación del amoníaco.
El coma hiperamonémico en neonatos es una emergencia médica que pone en peligro la vida.
Los tratamientos estándar como la hemofiltración y las intervenciones metabólicas fueron ineficaces.

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