Video Experimental Relacionado
Updated: Jun 22, 2026
11:06
Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
Cánceres hereditarios comunes e implicaciones para la atención primaria.
J Emery1, A Lucassen, M Murphy
1General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Forvie Site, CB2 2SR, Cambridge, UK. jde10@medschl.cam.ac.uk
Lancet (London, England)
|July 17, 2001
Resumen
Los descubrimientos genéticos identifican a las personas de alto riesgo de cánceres hereditarios. La atención primaria necesita estrategias para manejar el riesgo genético y guiar las pruebas genéticas y la vigilancia apropiadas.
Área de la Ciencia:
- Genética médica La genética médica.
- Oncología Oncología.
- Medicina de la Atención Primaria La medicina de la atención primaria es la medicina de la atención primaria.
Sus antecedentes:
- Los avances en la identificación de genes para el cáncer hereditario de mama, ovario y colorrectal han aumentado la conciencia pública y clínica.
- Esto ha llevado a un aumento en las referencias para asesoramiento genético, consulta quirúrgica y pruebas genéticas.
Objetivo del estudio:
- Revisar la evidencia para el manejo de individuos con mayor riesgo de cánceres hereditarios.
- Para resaltar las incertidumbres y discutir las implicaciones para la práctica de la atención primaria.
- Centrarse en los cánceres hereditarios comunes con un impacto clínico futuro significativo.
Principales métodos:
- Revisión de la evidencia publicada sobre el manejo del riesgo hereditario de cáncer.
- Centrarse en los síndromes comunes de cáncer hereditario.
- Discusión de las implicaciones para la integración de la medicina genética en la atención primaria.
Principales resultados:
- Aumento de la identificación de individuos en riesgo genético de cánceres comunes.
- Creciente demanda de pruebas genéticas y estrategias de vigilancia.
- Existen áreas de incertidumbre en los protocolos de gestión actuales.
Conclusiones:
- Los descubrimientos genéticos están transformando la comprensión de la predisposición al cáncer y la práctica clínica.
- Los profesionales de la atención primaria requieren apoyo para identificar y administrar eficazmente a los pacientes con mayor riesgo de cáncer hereditario.
- El desarrollo de estrategias para integrar la medicina genética en la atención primaria es crucial para la atención óptima del paciente y la asignación de recursos.
Videos de Conceptos Relacionados
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...