Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Atomic Nuclei: Nuclear Spin01:08

Atomic Nuclei: Nuclear Spin

All atomic particles possess an intrinsic angular momentum, or 'spin'. Electrons, protons, and neutrons each have a spin value of ½, although protons and neutrons in nuclei may have higher half-integer spins owing to energetic factors.
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...
Atomic Nuclei: Nuclear Spin State Overview01:03

Atomic Nuclei: Nuclear Spin State Overview

NMR-active nuclei have energy levels called 'spin states' that are associated with the orientations of their nuclear magnetic moments. In the absence of a magnetic field, the nuclear magnetic moments are randomly oriented, and the spin states are degenerate. When an external magnetic field is applied, the spin states have only 2 + 1 orientations available to them. A proton with = ½ has two available orientations. Similarly, for a quadrupolar nucleus with a nuclear spin value of one, the...
Toroids01:27

Toroids

A toroid is a closely wound donut-shaped coil constructed using a single conducting wire. In general, it is assumed that a toriod consists of multiple circular loops perpendicular to its axis.
When connected to a supply, the magnetic field generated in the toroid has field lines circular and concentric to its axis. Conventionally, the direction of this magnetic field is expressed using the right-hand rule. If the fingers of the right hand curl in the current direction, the thumb points in the...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Welding X65 for Sour Service: Microstructural Evolution and Mechanical Degradation of Pulsed GMAW Joints in H<sub>2</sub>S Environments.

Materials (Basel, Switzerland)·2026
Same author

Bibliometric analysis of global research trends in pediatric hearing impairment.

European annals of otorhinolaryngology, head and neck diseases·2026
Same author

High-definition transcranial direct current stimulation for depressive and other non-motor symptoms in Parkinson's disease: a randomised, sham-controlled, cross-over study.

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2026
Same author

Perinatal outcomes of twin pregnancies complicated by early twin-to-twin transfusion syndrome treated with fetoscopic laser surgery.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

DIFFERENTIAL ASSOCIATIONS BETWEEN PHYSICAL ACTIVITY AND GLYCEMIC CONTROL ACROSS BODY MASS INDEX IN TYPE 2 DIABETES: A COMPARATIVE ANALYSIS OF HBA1C AND FRUCTOSAMINE.

Georgian medical news·2026
Same author

Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) Into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report From the National Clinical Trials Network.

International journal of radiation oncology, biology, physics·2026
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 29, 2026

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
05:47

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

Published on: July 29, 2018

Una bobina en espiral con un núcleo fluoro.

B Bilgiçer1, A Fichera, K Kumar

  • 1Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio diseñó un sistema de péptidos fluorados para mejorar la estabilidad. El nuevo péptido fluorado demostró una mayor estabilidad y un punto de fusión más alto en comparación con su contraparte de hidrocarburos.

Más Videos Relacionados

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Tree Core Analysis with X-ray Computed Tomography
06:56

Tree Core Analysis with X-ray Computed Tomography

Published on: September 22, 2023

Videos de Experimentos Relacionados

Last Updated: Jun 29, 2026

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
05:47

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

Published on: July 29, 2018

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Tree Core Analysis with X-ray Computed Tomography
06:56

Tree Core Analysis with X-ray Computed Tomography

Published on: September 22, 2023

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Química del péptido Química del péptido
  • Biología Estructural Biología estructural.

Sus antecedentes:

  • Las estructuras en espiral en espiral son cruciales en las interacciones proteína-proteína.
  • El diseño de sistemas de péptidos estables es importante para aplicaciones biomoleculares.
  • Los aminoácidos fluorados ofrecen propiedades únicas para la modificación de péptidos.

Objetivo del estudio:

  • Diseñar y sintetizar un sistema de péptidos altamente fluorados basado en la bobina enrollada GCN4.
  • Para investigar las características estructurales y de estabilidad del péptido fluorado.
  • Explorar el potencial de los péptidos fluorados en sistemas de autoensamblaje.

Principales métodos:

  • Diseño y síntesis de péptidos que incorporan aminoácidos no naturales (5,5,5-trifluoroleucina y 4,4,4-trifluorovalina).
  • Espectroscopia de dicroísmo circular para evaluar la estructura secundaria.
  • Ultracentrifugado analítico para determinar el estado oligomérico.
  • Experimentos de desnaturalización de clorhidrato de guanidinio para medir la energía libre en desarrollo.

Principales resultados:

  • El péptido fluorado es altamente alfa-hélico en solución.
  • Forma una especie dimérica estable.
  • El péptido fluorado exhibe una temperatura de fusión 15 ° C más alta y una mayor estabilidad en comparación con un control de hidrocarburos.
  • La energía libre aparente de despliegue es aproximadamente 1,0 kcal/mol mayor para el péptido fluorado.

Conclusiones:

  • La incorporación de grupos trifluorometilo mejora la estabilidad del péptido.
  • Los grupos trifluorometilo hidrofóbicos se secuestran efectivamente del disolvente acuoso.
  • Este trabajo presenta un nuevo enfoque para el diseño de sistemas de autoensamblaje utilizando propiedades de solubilidad ortogonales.