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Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
El uso de inhibidores de la proteasa del virus de la inmunodeficiencia humana-1 está asociado con cambios en las
J H Stein1, M A Klein, J L Bellehumeur
1Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA.
Circulation
|July 18, 2001
Resumen
Los inhibidores de la proteasa del virus de la inmunodeficiencia humana (IPVI) causan cambios dañinos en el colesterol y perjudican la función de los vasos sanguíneos, aumentando el riesgo de aterosclerosis. El monitoreo y el tratamiento de la dislipidemia en pacientes que toman estos medicamentos es crucial.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Enfermedades infecciosas Enfermedades infecciosas.
- Farmacología Farmacología.
Sus antecedentes:
- Los inhibidores de la proteasa del virus de la inmunodeficiencia humana (IPVI) están relacionados con problemas metabólicos como la hiperlipidemia y la obesidad.
- El impacto de las IPV del VIH en el riesgo de enfermedad vascular aterosclerótica sigue sin estar claro.
- Este estudio investiga las anormalidades de las lipoproteínas y la función endotelial en individuos infectados por el VIH que usan inhibidores de la lipoproteína.
Objetivo del estudio:
- Para caracterizar las anomalías de lipoproteínas en pacientes con VIH en IPP.
- Evaluar el significado fisiopatológico de estos cambios en la disfunción endotelial.
Principales métodos:
- Estudio transversal de 37 adultos infectados por el VIH-1 en tratamiento antirretroviral.
- Dividido en 22 sobre IP (grupo 1) y 15 no sobre IP (grupo 2).
- Se midieron los lípidos, las lipoproteínas (enzimáticas, RMN) y la vasodilatación mediada por el flujo de la arteria braquial (FMD) a través de ultrasonido.
Principales resultados:
- El grupo 1 tenía un colesterol total y triglicéridos más altos, con niveles elevados de IDL y VLDL.
- El grupo 1 exhibió deterioro de la fiebre aftosa (2.6+/-4.6%), lo que indica una disfunción endotelial significativa.
- El grupo 2 mostró fiebre aftosa normal (8,1+/6,7%).
- Los niveles de lipoproteínas (chilomicrón, VLDL, IDL, HDL) predijeron la fiebre aftosa en el grupo 1.
Conclusiones:
- Los IPV del VIH están asociados con cambios en las lipoproteínas aterogénicas y disfunción endotelial.
- Estas alteraciones metabólicas y vasculares aumentan la predisposición a la aterosclerosis.
- Se recomienda el monitoreo regular y el manejo de la dislipidemia para los pacientes con IPV.
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