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Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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La anemia del corredor.

C V Dang1

  • 1Ross Research Bldg, Room 1025, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA. cvdang@jhmi.edu

JAMA
|August 10, 2001
PubMed
Resumen
Este resumen es generado por máquina.

La anemia del corredor, caracterizada por una anemia leve en atletas de resistencia, es el resultado de la expansión del volumen plasmático y la descomposición de los glóbulos rojos. Reconocer esta condición puede evitar procedimientos diagnósticos innecesarios para la fatiga en los corredores.

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Área de la Ciencia:

  • Medicina del Deporte Medicina del Deporte La medicina del deporte es el deporte.
  • Hematología Hematología.

Sus antecedentes:

  • La anemia macrocítica se presenta con fatiga, lo que provoca diagnósticos diferenciales desde déficits nutricionales hasta síndromes mielodisplásicos.
  • Los atletas de resistencia pueden presentar anemia, lo que requiere una cuidadosa consideración de etiologías específicas más allá de las causas comunes.

Objetivo del estudio:

  • Para resaltar el reconocimiento de la anemia del corredor en atletas que presentan fatiga y anemia.
  • Para diferenciar la anemia del corredor de otras causas de anemia en corredores de larga distancia.
  • Hacer hincapié en la importancia del diagnóstico temprano para evitar exhaustivos exámenes médicos.

Principales métodos:

  • Revisión de casos clínicos centrados en la historia clínica del paciente y la presentación de síntomas.
  • Análisis de los mecanismos fisiológicos que contribuyen a la anemia en corredores.
  • Comparación de la anemia del corredor con otros diagnósticos diferenciales para la anemia macrocítica.

Principales resultados:

  • La anemia del corredor está relacionada con la expansión del volumen plasmático y la hemólisis inducida por los pies, lo que lleva a la hemoglobinuria.
  • La pérdida de sangre gastrointestinal puede ser un factor adicional en la anemia entre los corredores de larga distancia.
  • La anemia leve, cuando es bien tolerada por un corredor dedicado, justifica la consideración de la anemia del corredor.

Conclusiones:

  • La identificación temprana de la anemia del corredor es vital para los atletas que experimentan fatiga y anemia.
  • Una historia completa del paciente es clave para diagnosticar la anemia del corredor y evitar pruebas innecesarias.
  • Se debe considerar la anemia del corredor en corredores ávidos con anemia leve y bien tolerada y síntomas relacionados.