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Updated: Jul 21, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

Estructura cristalina de un IGG humano neutralizante contra el VIH-1: una plantilla para el diseño de vacunas

E O Saphire1, P W Parren, R Pantophlet

  • 1Department of Molecular Biology, Department of Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|August 11, 2001
PubMed
Resumen

La estructura cristalina del anticuerpo humano IgG1 b12 revela un bucle CDR H3 único que neutraliza el VIH-1. Este hallazgo explica los desafíos en el desarrollo de anticuerpos similares y ayuda en el diseño de nuevas vacunas contra el VIH-1.

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