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Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
Axial and Appendicular Muscles01:18

Axial and Appendicular Muscles

Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
Muscles for Facial Expressions01:14

Muscles for Facial Expressions

The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
Muscles that Move the Arm01:31

Muscles that Move the Arm

Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
The pectoralis major has two origins. Its clavicular head originates on the medial half of the clavicle. In contrast, the sternocostal head originates on the costal cartilages of ribs 1-6, the sternum, and the aponeurosis of the external oblique of the...
Muscles that Move the Forearm01:16

Muscles that Move the Forearm

The muscles that move the forearms can be divided into four groups: forearm flexors, forearm extensors, forearm pronators, and forearm supinators. The flexors and extensors act on the elbow joint, while the pronators and supinators act on the radioulnar joints.
Forearm Flexors
The biceps brachii, brachialis, and brachioradialis are forearm flexors. The biceps brachii is made up of two heads. Its long head originates at the supraglenoid tubercle of the scapula, whereas that of the short head is...

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Video Experimental Relacionado

Updated: Jun 24, 2026

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
14:36

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

Published on: February 9, 2013

Modelo de módulos autónomos periféricos y un plexo miovésico en la función normal y hiperactiva de la vejiga.

M J Drake1, I W Mills, J I Gillespie

  • 1Tyne Micturition Research Group, School of Surgical Sciences, Medical School, University of Newcastle upon Tyne NE2 4HH, UK. marcus.drake@doctors.org.uk

Lancet (London, England)
|August 15, 2001
PubMed
Resumen

La actividad del sistema nervioso periférico puede desempeñar un papel más importante en el control de la vejiga de lo que se pensaba. Este estudio propone que la hiperactividad de la vejiga se deriva de desequilibrios en la actividad autónoma periférica dentro de las estructuras musculares modulares del detrusor.

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Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
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Área de la Ciencia:

  • Urología Urología Urología.
  • La neurociencia es la neurociencia.
  • Fisiología Fisiología Fisiología.

Sus antecedentes:

  • La función normal de la vejiga se atribuye principalmente al control del sistema nervioso central (SNC).
  • Existe una contribución periférica potencial, aunque subestimada, al control de la vejiga.

Objetivo del estudio:

  • Proponer un nuevo modelo de control de la vejiga que involucre los mecanismos del sistema nervioso periférico.
  • Investigar el papel de la actividad autónoma periférica en la hiperactividad del detrusor.

Principales métodos:

  • Conceptualización de la disposición modular del músculo detrusor.
  • La hipótesis es que un plexo miovésico periférico controla estos módulos.
  • Proponer un nuevo mecanismo para la hiperactividad del detrusor basado en la actividad periférica.

Principales resultados:

  • El músculo detrusor puede organizarse en módulos funcionales.
  • Un plexo miovesical periférico, que incluye ganglios y células intersticiales, puede regular estos módulos.
  • La hiperactividad del detrusor podría surgir de un equilibrio alterado de excitación e inhibición dentro de estos módulos periféricos.

Conclusiones:

  • El sistema nervioso periférico influye significativamente en la función de la vejiga.
  • La hiperactividad del detrusor puede estar relacionada con la desregulación de la actividad autónoma periférica.
  • Dirigirse a las estructuras periféricas ofrece nuevas estrategias terapéuticas potenciales para la hiperactividad de la vejiga.