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Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
La disminución de la coagulabilidad no tiene ningún efecto clínicamente relevante en la aterogénesis: observaciones
A Srámek1, J H Reiber, W B Gerrits
1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden.
Circulation
|August 15, 2001
Resumen
Las personas con trastornos hemorrágicos hereditarios como la hemofilia y la enfermedad de von Willebrand muestran una protección mínima contra el desarrollo de la aterosclerosis. Su reducida capacidad de coagulación tiene un impacto limitado en la progresión de esta enfermedad cardiovascular.
Área de la Ciencia:
- Investigación de enfermedades cardiovasculares.
- Hematología Hematología.
- La patogénesis y la patogénesis de la aterosclerosis.
Sus antecedentes:
- La hemostasis juega un papel clave en la formación de trombos arteriales, impactando en la enfermedad cardiovascular isquémica.
- La evidencia emergente sugiere que la hemostasis también puede influir en la atherogénesis.
- Este estudio explora si las tendencias hemorrágicas hereditarias ofrecen protección contra la aterosclerosis.
Objetivo del estudio:
- Investigar el efecto protector potencial de las tendencias hemorrágicas hereditarias contra el desarrollo de la aterosclerosis.
- Para cuantificar los cambios ateroscleróticos tempranos en individuos con trastornos hemorrágicos en comparación con controles sanos.
Principales métodos:
- Ultrasonografía de modo B utilizada para medir el grosor de la íntima-media en las arterias carótida y femoral.
- El estudio incluyó a 76 individuos con tendencias hemorrágicas hereditarias (hemofilia, enfermedad de von Willebrand) y 142 controles sanos.
- Las mediciones validadas en 77 individuos con aterosclerosis probada y 34 controles sanos.
Principales resultados:
- Se observaron diferencias significativas en el grosor de la intima-media entre los pacientes con aterosclerosis y los controles (arteria femoral: 0,53 mm).
- Las personas con tendencias hemorrágicas mostraron solo una reducción mínima en el espesor íntima-media de la arteria femoral (diferencia ajustada: -0.078 mm).
- Los pacientes con hemofilia de moderada a severa exhibieron las paredes vasculares más delgadas.
Conclusiones:
- La hipocoagulabilidad asociada con la hemofilia o la enfermedad de von Willebrand ofrece una protección limitada contra la atherogénesis.
- El impacto de los trastornos hemorrágicos en la progresión de la aterosclerosis parece mínimo.
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