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BAFF-R, un receptor TNF recientemente identificado que interactúa específicamente con BAFF
J S Thompson1, S A Bixler, F Qian
1Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
Science (New York, N.Y.)
|August 18, 2001
Resumen
Los científicos descubrieron un nuevo receptor, BAFF-R, crucial para la supervivencia de las células B. Este hallazgo explica cómo el factor de activación de las células B (BAFF) regula la homeostasis de las células B e identifica a BAFF-R como el receptor primario para la supervivencia de las células B maduras.
Área de la Ciencia:
- Inmunología Inmunología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- La homeostasis de las células B está regulada por el factor de activación de las células B (BAFF) de la familia del factor de necrosis tumoral (TNF).
- Se sabe que el BAFF interactúa con los receptores BCMA y TACI.
Objetivo del estudio:
- Para identificar y caracterizar nuevos receptores para BAFF.
- Para dilucidar el papel de estos receptores en la función de las células B.
Principales métodos:
- Pruebas de unión ligando-receptor. ensayos de unión ligando-receptor.
- Análisis genético de ratones A/WySnJ con un locus BAFF-R alterado.
- Análisis fenotípico de poblaciones de células B.
Principales resultados:
- Se identificó un tercer receptor BAFF, denominado BAFF-R.
- BAFF-R exhibe una unión específica a BAFF, lo que sugiere una interacción única.
- La alteración del locus BAFF-R en ratones A/WySnJ conduce a un fenotipo de células B similar al de ratones con deficiencia de BAFF.
Conclusiones:
- BAFF-R es un receptor principal para BAFF.
- BAFF-R juega un papel crítico en la mediación de la supervivencia de las células B maduras y el mantenimiento de la homeostasis de las células B.
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