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Síntesis total asimétrica de la ent-(-)-roseofilina: asignación de la configuración absoluta de la misma

D L Boger1, J Hong

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|August 30, 2001
PubMed
Resumen

Los investigadores sintetizaron el enantiómero no natural del antibiótico antitumoral roséofilina. Esta forma antinatural, la ent-(-) -roseofilina, demostró inesperadamente una potencia 2-10 veces mayor en ensayos citotóxicos en comparación con la roseofilina natural.

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