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Mecanismos dependientes del portal para la acción de la flecainida en los síndromes de arritmia vinculados a SCN5A

P C Viswanathan1, C R Bezzina, A L George

  • 1Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, USA.

Circulation
|September 6, 2001
PubMed
Resumen

Las mutaciones del canal de sodio cardíaco (SCN5A) causan los síndromes LQT3 y Brugada. Los defectos de la puerta de inactivación en estas mutaciones aumentan la sensibilidad a la flecainida, causando potencialmente arritmias peligrosas.

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