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Toxicidad ocular y exposición prenatal a cloroquina o hidroxicloroquina para enfermedades reumáticas
Lancet (London, England)
|September 21, 2001
Resumen
La cloroquina e hidroxicloroquina se usan para enfermedades reumáticas y pueden causar retinopatía. Los exámenes oftalmológicos de 21 niños expuestos durante el embarazo no encontraron anormalidades oculares, lo que sugiere un bajo riesgo.
Área de la Ciencia:
- Oftalmología Oftalmología.
- Reumatología Reumatología.
- Farmacología Farmacología.
Sus antecedentes:
- Los tratamientos de enfermedades reumáticas como la cloroquina y la hidroxicloroquina conllevan un riesgo de retinopatía pigmentaria.
- Los datos de seguridad con respecto a la exposición in utero a estos medicamentos son limitados.
Objetivo del estudio:
- Evaluar la seguridad ocular de la exposición a la cloroquina e hidroxicloroquina durante el embarazo.
- Para evaluar las posibles anomalías oftalmológicas en los niños nacidos de madres que usan estos medicamentos.
Principales métodos:
- Se realizaron exámenes oftalmológicos a 21 niños cuyas madres usaron cloroquina o hidroxicloroquina durante la gestación.
- Se registraron las dosis maternas de fármacos y la duración de la exposición gestacional.
Principales resultados:
- No se detectaron anormalidades oftalmológicas en ninguno de los 21 niños examinados.
- La dosis materna diaria promedio fue de 317 mg de hidroxicloroquina y 332 mg de cloroquina.
- La duración media de la exposición gestacional fue de 7,2 meses.
Conclusiones:
- El uso terapéutico de cloroquina e hidroxicloroquina durante el embarazo no resultó en toxicidad ocular detectable en la descendencia.
- Estos hallazgos sugieren que estos medicamentos pueden ser relativamente seguros para el desarrollo ocular fetal cuando se usan terapéuticamente.
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