Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

The Extracellular Matrix

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.

Mechanism of Filopodia Formation

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

The Extracellular Matrix

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning.

The Journal of comparative neurology·2004

Same author

Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates.

Development genes and evolution·2003

Same author

Detailed field pattern is intrinsic to the embryonic mouse hippocampus early in neurogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

Same author

Patterning the mammalian cerebral cortex.

Current opinion in neurobiology·2001

Same author

LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.

Mechanisms of development·2001

Same author

Increase in cap- and IRES-dependent protein synthesis by overproduction of translation initiation factor eIF4G.

Biochemical and biophysical research communications·2000

Search research articles

Video Experimental Relacionado

Updated: Jul 11, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

El patrón de la neocorteza por la molécula de señalización secretada FGF8F8.

T Fukuchi-Shimogori¹, E A Grove

¹Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA.

Science (New York, N.Y.)

|September 22, 2001

Resumen

La señalización del factor de crecimiento de los fibroblastos 8 (FGF8) regula el desarrollo del área neocortical de los mamíferos. La manipulación de los niveles o fuentes de FGF8 altera los límites del área y puede causar duplicaciones, revelando su papel en la especificación de la identidad posicional.

Más Videos Relacionados

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

Videos de Experimentos Relacionados

Last Updated: Jul 11, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos

Published on: July 21, 2021

Área de la Ciencia:

La neurociencia es la neurociencia.
Biología del desarrollo Biología del desarrollo.
Genética La genética.

Sus antecedentes:

El neocórtex de los mamíferos está organizado en distintas áreas funcionales.
Los mecanismos moleculares que impulsan la formación de este mapa de área durante la neurogénesis siguen siendo en gran medida desconocidos.

Objetivo del estudio:

Investigar el papel del Factor de Crecimiento de Fibroblastos 8 (FGF8) en el desarrollo del área neocortical. mapa.
Aclarar los mecanismos moleculares subyacentes a la especificación de la identidad posicional en el neocórtex.

Principales métodos:

Utilizó la transferencia de genes mediada por electroporación en embriones de ratón.
Manipuló la señal endógena anterior de FGF8 aumentando o reduciendo sus niveles.
Se introdujo una fuente posterior ectópica de FGF8.8.

Principales resultados:

El aumento de la señal anterior de FGF8 desplazó posteriormente los límites del área neocortical.
La reducción de la señal anterior FGF8 desplazó los límites del área anteriormente.
La fuente de FGF8 posterior ectópica indujo duplicaciones parciales de área, evidenciadas por campos de barril somatosensorial ectópico.

Conclusiones:

La señalización de FGF8, que se origina en el telencéfalo anterior, es un regulador clave del desarrollo del mapa de área neocortical.
FGF8 juega un papel crítico en la especificación de la identidad posicional dentro del desarrollo de la neocórtex.