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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
Published on: May 2, 2012
Placa coronaria inestable y su relación con el calcio coronario
1Department of Cardiology, University Clinic Essen, Germany. Axel.Schmermund@uni-essen.de
Circulation
|October 3, 2001
Resumen
La imagen de calcio coronario identifica a los pacientes con alto riesgo de síndromes coronarios agudos, incluso si las placas inestables no se visualizan directamente. El calcio coronario extenso indica un mayor riesgo de ataque cardíaco y muerte.
Área de la Ciencia:
- Cardiología Cardiología.
- Radiología Radiología.
- La medicina preventiva es la medicina preventiva de las enfermedades.
Sus antecedentes:
- El calcio coronario está relacionado con el desarrollo de la placa aterosclerótica.
- La tomografía computarizada con haz de electrones (EBCT) permite la medición cuantitativa del calcio coronario.
- Distinguir las placas inestables de las estables basadas en la presencia de calcio es un desafío.
Objetivo del estudio:
- Para explorar la importancia clínica del calcio coronario en la identificación de pacientes en riesgo de síndromes coronarios agudos.
- Para determinar si la imagen del calcio coronario puede identificar al "paciente inestable" en lugar de sólo las placas inestables.
Principales métodos:
- Utilizando la tomografía computarizada de haz de electrones (EBCT) para mediciones cuantitativas del calcio coronario.
- Revisión de los hallazgos de estudios histopatológicos y prospectivos sobre el calcio coronario y las características de la placa.
- Analizando la asociación entre el calcio coronario extenso y los resultados cardiovasculares adversos.
Principales resultados:
- El calcio coronario es una característica frecuente de las placas rotas, pero no diferencia de manera confiable las placas estables de las inestables.
- Si bien no identifica placas inestables localizadas, las imágenes de calcio coronario pueden identificar a los pacientes con mayor riesgo.
- La mayoría de los pacientes con síndromes coronarios agudos tienen calcio coronario medible, lo que indica una enfermedad de placa subyacente.
- El calcio coronario extenso detectado por EBCT está asociado con una mayor incidencia de infarto de miocardio, revascularización y muerte cardíaca.
Conclusiones:
- La imagen del calcio coronario es valiosa para identificar a los pacientes en riesgo de síndromes coronarios agudos.
- Se necesitan más ensayos prospectivos a gran escala para definir los subgrupos que se benefician más de la evaluación cuantitativa del calcio coronario.
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