Región de clase II del CMH, gen CTLA4 y oftalmopatía en pacientes con enfermedad de Graves

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A Allahabadia, J M Heward, R Nithiyananthan

Lancet (London, England)

|October 5, 2001

Resumen

El hipertiroidismo de Graves puede causar problemas oculares, pero las causas genéticas no están claras. Los investigadores encontraron que los genes específicos, MHC clase II y CTLA4, no parecen aumentar el riesgo de desarrollar estas complicaciones oculares.

Área de la Ciencia:

Endocrinología e Inmunología.
Oftalmología Oftalmología.
Genética Humana Genética Humana.

Sus antecedentes:

El hipertiroidismo de Graves afecta hasta el 50% de los pacientes con oftalmopatía asociada a la tiroides (TAO).
Los factores genéticos subyacentes que contribuyen al desarrollo de TAO siguen siendo en gran medida desconocidos.
Este estudio se centra en dos loci clave de susceptibilidad genética para la enfermedad de Graves: la región MHC clase II y el gen citotóxico del antígeno linfocitario T-4 (CTLA4).

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