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Las polimerasas de ADN propensas a errores: nuevas estructuras y los beneficios de la infidelidad

E C Friedberg¹, P L Fischhaber, C Kisker

¹Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. errol.friedberg@utsouthwestern.edu

|October 12, 2001

Resumen

Las polimerasas de ADN propensas a errores recientemente descubiertas tienen nuevas estructuras que explican su baja fidelidad. Estas enzimas son cruciales para eludir el daño de la base del ADN durante la replicación.

Área de la Ciencia:

Biología Molecular Biología Molecular
La bioquímica es la bioquímica.
Genética La genética.

Sus antecedentes:

Las polimerasas de ADN son esenciales para la replicación y reparación del ADN.
Algunas polimerasas de ADN exhiben una actividad propensa a errores, crucial para la síntesis de la traslación.
La síntesis de traslación permite que la replicación proceda más allá de las lesiones del ADN.

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