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Sobrevivencia después del trasplante de médula ósea de donantes hermanos seropositivos para el citomegalovirus
Lancet (London, England)
|October 13, 2001
Resumen
La seropositividad del citomegalovirus del donante mejora la supervivencia en pacientes con leucemia sometidos a trasplante de médula ósea, particularmente en receptores positivos para HLA-A2. Esto sugiere una mayor actividad del injerto contra la leucemia de las células T específicas del citomegalovirus.
Área de la Ciencia:
- Inmunología Inmunología.
- Hematología Hematología.
- Oncología Oncología.
Sus antecedentes:
- Investigó el impacto del serostato del citomegalovirus (CMV) del donante en los resultados en 103 pacientes con leucemia que recibieron trasplantes de médula ósea hermanos idénticos a HLA.
- Centrado en el papel de la restricción de HLA-A2 en la actividad de las células T contra el CMV y las células leucémicas.
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