Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Dense Connective Tissue01:13

Dense Connective Tissue

Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Efficacy and user preference of two CO2 detectors in an infant mannequin randomized crossover trial.

European journal of pediatrics·2013
Same author

A longitudinal study of relations between job stressors and job strains while controlling for prior negative affectivity and strains.

The Journal of applied psychology·2000
Same author

The pediatrician and the sexually active adolescent. Treatment of common menstrual disorders.

Pediatric clinics of North America·1997
Same author

Vaginal ectopic ureter with Gartner's duct cyst.

The Journal of urology·1997
Same author

Plasma acylation-stimulating protein in coronary artery disease.

Arteriosclerosis, thrombosis, and vascular biology·1997
Same author

Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.

Arteriosclerosis, thrombosis, and vascular biology·1997
Same journal

Eugene Braunwald, MD, 1929-2026.

Circulation·2026
Same journal

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026).

Circulation·2026
Same journal

Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry.

Circulation·2026
Same journal

Heart Failure Occurring in the Perinatal Period: A Scientific Statement From the American Heart Association.

Circulation·2026
Same journal

Correction to: 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026
Same journal

Correction to: The Natural History of Massive Left Ventricular Hypertrophy in Pediatric Hypertrophic Cardiomyopathy: A Multiregistry Analysis.

Circulation·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jun 30, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Lipoproteínas de alta densidad y función endotelial.

B J O'Connell1, J Genest

  • 1Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada.

Circulation
|October 17, 2001
PubMed
Resumen
Este resumen es generado por máquina.

Los altos niveles de colesterol HDL y la apolipoproteína A-I protegen contra la enfermedad de las arterias coronarias al facilitar la eliminación del colesterol. Estas partículas participan en interacciones complejas que influyen en varios procesos celulares vitales para la salud cardiovascular.

Más Videos Relacionados

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
08:14

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
08:19

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Published on: April 22, 2019

Videos de Experimentos Relacionados

Last Updated: Jun 30, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
08:14

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

Published on: September 29, 2015

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
08:19

Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

Published on: April 22, 2019

Área de la Ciencia:

  • La bioquímica es la bioquímica.
  • Biología Cardiovascular Biología Cardiovascular
  • La medicina molecular es una medicina molecular.

Sus antecedentes:

  • Los niveles elevados de colesterol de lipoproteína de alta densidad (HDL) y de apolipoproteína A-I (ApoA-I) se asocian con la protección contra la enfermedad de las arterias coronarias (CAD).
  • Las partículas de HDL juegan un papel crucial en el transporte inverso del colesterol, moviendo el colesterol de los tejidos periféricos al hígado para su excreción.
  • La comprensión de los mecanismos moleculares de la interacción de HDL es clave para el desarrollo de terapias CAD.

Objetivo del estudio:

  • Aclarar los intrincados mecanismos subyacentes a las interacciones de las lipoproteínas en el contexto de la salud cardiovascular.
  • Explorar cómo las interacciones de las partículas HDL influyen en las vías celulares relevantes para la aterosclerosis y la CAD.

Principales métodos:

  • El estudio se centra en las interacciones moleculares y celulares de las partículas de HDL, específicamente con la apolipoproteína AI.
  • Examina las interacciones no bilayer, incluida la interacción proteína-receptor, las interacciones fosfolípidas y la activación de la señalización celular.

Principales resultados:

  • La interacción de las lipoproteínas es compleja, ya que implica la unión de proteínas-receptores específicos y los contactos de fosfolípidos cargados, no sólo la fusión de membranas.
  • Estas interacciones desencadenan las vías de señalización celular que regulan las funciones celulares críticas.
  • Los principales procesos regulados incluyen la función vasomotriz, la activación de las plaquetas, la trombosis / trombolisis, la adhesión celular, la apoptosis, la proliferación y la homeostasis del colesterol.

Conclusiones:

  • El colesterol HDL y ApoA-I confieren protección contra la CAD a través de interacciones moleculares sofisticadas.
  • Estas interacciones modulan una amplia gama de procesos celulares, lo que afecta la salud y la enfermedad vascular.
  • Investigaciones adicionales sobre estas vías podrían revelar nuevos objetivos terapéuticos para la CAD.