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Nivel circulante elevado de grelina en caquexia asociada con insuficiencia cardíaca crónica: relaciones entre la
N Nagaya1, M Uematsu, M Kojima
1Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan. nagayann@hsp.ncvc.go.jp
Circulation
|October 24, 2001
Resumen
Los niveles plasmáticos de grelina están elevados en pacientes con insuficiencia cardíaca crónica (ICC) que experimentan caquexia. Este aumento en la grelina puede ser una respuesta compensatoria al estado catabólico en estos pacientes.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Cardiología Cardiología.
- El metabolismo es el metabolismo.
Sus antecedentes:
- La grelina, un péptido liberador de la hormona del crecimiento (GH), influye en el equilibrio energético y la adiposidad.
- La insuficiencia cardíaca crónica (ICC) a menudo se asocia con la caquexia, un síndrome metabólico complejo.
- El papel de la grelina en la fisiopatología de la caquexia relacionada con la insuficiencia cardíaca requiere investigación.
Objetivo del estudio:
- Investigar el papel y los niveles de grelina en pacientes con insuficiencia cardíaca crónica (ICC).
- Para determinar la asociación entre la grelina y la caquexia en pacientes con ECH.
- Para explorar las correlaciones entre la grelina y otros factores catabólicos / anabólicos en la ICH.
Principales métodos:
- Los niveles plasmáticos de grelina se midieron en 74 pacientes con insuficiencia cardíaca congestiva y 12 controles.
- Los pacientes con CHF se clasificaron en grupos caquéticos (n=28) y no caquéticos (n=46).
- Las mediciones incluyeron GH, TNF-alfa, norepinefrina y angiotensina II.
Principales resultados:
- La grelina plasmática fue significativamente más alta en pacientes con CHF caquética en comparación con pacientes sin CHF caquética (237+/-18 vs. 147+/-10 fmol/mL, P<0.001).
- Se observaron niveles elevados de GH, TNF-alfa, norepinefrina y angiotensina II en pacientes con CHF caquética.
- La grelina plasmática se correlaciona positivamente con la GH y el TNF-alfa, y negativamente con el índice de masa corporal.
Conclusiones:
- Los niveles elevados de grelina plasmática se asocian con la caquexia en pacientes con insuficiencia cardíaca congestiva.
- El aumento de grelina puede actuar como un mecanismo compensatorio en el desequilibrio catabólico-anabólico de la CHF caquética.
- El papel de la ghrelina en el equilibrio energético merece un estudio más profundo en el contexto de la caquexia por CHF.
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