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Protein Modifications: Protein Kinases and Phosphatases

Protein Modifications: Protein Kinases and Phosphatases

CD40L soluble y riesgo cardiovascular en mujeres

U Schönbeck¹, N Varo, P Libby

¹Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. uschoenbeck@rics.bwh.harvard.edu

|November 7, 2001

Resumen

Los niveles elevados de CD40L soluble (sCD40L) en mujeres sanas pueden predecir futuros eventos cardiovasculares como ataque cardíaco o accidente cerebrovascular. Este hallazgo sugiere que sCD40L podría ser un biomarcador temprano para el riesgo vascular.

Área de la Ciencia:

Investigación de enfermedades cardiovasculares.
Inmunología y aterosclerosis.

Sus antecedentes:

La vía de señalización CD40/CD40L está implicada en la promoción de la aterosclerosis.
Se observa un aumento del CD40L soluble (sCD40L) en pacientes con angina de pecho inestable.

Objetivo del estudio:

Para investigar si los niveles elevados de sCD40L circulante preceden a la aparición de síntomas cardiovasculares agudos.

Principales métodos:

Estudio prospectivo de casos y controles anidados que involucra a mujeres sanas de mediana edad.
Medición de las concentraciones plasmáticas basales de sCD40L.
Un seguimiento de 4 años para identificar eventos cardiovasculares (infarto de miocardio, accidente cerebrovascular, muerte cardiovascular).

Principales resultados:

Las concentraciones medias de sCD40L fueron significativamente más altas en las mujeres que más tarde experimentaron eventos cardiovasculares en comparación con los controles.
Las mujeres con sCD40L por encima del percentil 95 tenían un riesgo 3,3 veces mayor de eventos cardiovasculares futuros.
Esta asociación se mantuvo significativa después de ajustar por los factores de riesgo cardiovasculares tradicionales.

Conclusiones:

Las altas concentraciones plasmáticas de sCD40L se asocian con un mayor riesgo vascular en mujeres aparentemente sanas.
sCD40L puede servir como un biomarcador predictivo potencial para eventos cardiovasculares.

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