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Ciclos menstruales largos o muy irregulares como marcador del riesgo de diabetes mellitus tipo 2
C G Solomon1, F B Hu, A Dunaif
1Division of Women's Health, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA. cgsolomon@bics.bwh.harvard.edu
JAMA
|December 26, 2001
Resumen
Las mujeres con ciclos menstruales largos o irregulares enfrentan un riesgo duplicado de desarrollar diabetes tipo 2. Este mayor riesgo de diabetes mellitus tipo 2 (DM) está presente incluso en personas no obesas.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Salud reproductiva y salud reproductiva.
- Trastornos metabólicos Los trastornos metabólicos son trastornos metabólicos que se producen en el cuerpo.
Sus antecedentes:
- La oligomenorrea está relacionada con la resistencia a la insulina y la intolerancia a la glucosa.
- El riesgo prospectivo de diabetes mellitus tipo 2 (DM) asociado con la oligomenorrea no está bien establecido.
Objetivo del estudio:
- Evaluar prospectivamente la asociación entre ciclos menstruales largos o irregulares y el riesgo futuro de DM tipo 2.
- Para determinar si los patrones del ciclo menstrual en la edad adulta temprana predicen el desarrollo de DM tipo 2.
Principales métodos:
- Se utilizaron datos de la cohorte II del Estudio de Salud de Enfermeras de observación prospectiva.
- Analizó los patrones del ciclo menstrual a las edades de 18 a 22 años en más de 100.000 mujeres sin DM previa.
- Se rastrearon incidentes de casos de DM tipo 2 durante un período de seguimiento hasta 1997.
Principales resultados:
- Las mujeres con ciclos menstruales de más de 40 días o ciclos muy irregulares tenían un aumento de 2,08 veces el riesgo de DM tipo 2.
- Este riesgo elevado se observó en varias categorías de índice de masa corporal, incluidas las mujeres no obesas.
- La asociación entre los ciclos irregulares y el riesgo de DM tipo 2 fue más pronunciada en las mujeres obesas.
Conclusiones:
- Los ciclos menstruales largos o muy irregulares son un predictor significativo del desarrollo futuro de DM tipo 2.
- El aumento del riesgo de diabetes mellitus tipo 2 no es únicamente atribuible a la obesidad.
- La regularidad del ciclo menstrual en la edad adulta puede servir como un indicador de la salud metabólica y el riesgo futuro de diabetes.
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