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La disminución de la reserva de flujo sanguíneo coronario durante la hiperlipidemia es secundaria a un aumento de la

S J Rim1, H Leong-Poi, J R Lindner

  • 1Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA, USA.

Circulation
|November 28, 2001
PubMed
Resumen
Este resumen es generado por máquina.

En la hiperlipidemia, el aumento de la viscosidad de la sangre, no la vasomoción anormal, aumenta la resistencia capilar. Este aumento de la viscosidad deteriora la reserva de flujo sanguíneo coronario (FCB) durante la hiperemia máxima.

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Área de la Ciencia:

  • Fisiología cardiovascular fisiología cardiovascular.
  • Reología de la sangre Reología de la sangre.
  • Trastornos metabólicos Los trastornos metabólicos son trastornos metabólicos que se producen en el cuerpo.

Sus antecedentes:

  • La resistencia capilar afecta significativamente el flujo sanguíneo durante la hiperemia máxima.
  • La viscosidad de la sangre es un determinante clave de la resistencia capilar.
  • La hiperlipidemia está asociada con una reserva anormal del flujo sanguíneo coronario (FCB).

Objetivo del estudio:

  • Investigar si el aumento de la viscosidad sanguínea o la vasomoción coronaria anormal subyace a la reducción de la reserva de CBF en la hiperlipidemia.
  • Para dilucidar los mecanismos reológicos que afectan el flujo sanguíneo coronario durante la hiperlipidemia.

Principales métodos:

  • La hiperemia máxima fue inducida en perros usando adenosina.
  • Los niveles séricos de triglicéridos se elevaron con el uso de infusiones de Intralipid.
  • Se midió la viscosidad sanguínea, la resistencia vascular miocárdica (MVR) y el flujo sanguíneo miocárdico hiperémico (MBF).
  • La microscopia intravital en ratones del músculo cremaster confirmó los hallazgos.

Principales resultados:

  • Los niveles séricos de triglicéridos están fuertemente correlacionados con el aumento de la viscosidad sanguínea (r=0,82).
  • Ningún cambio en el volumen sanguíneo coronario o miocárdico indicó una falta de vasomoción.
  • El aumento de los niveles de triglicéridos condujo a un mayor MVR (r=0,84) y a una reducción del MBF hiperémico (r=-0,64) y de la velocidad (r=-0,56).

Conclusiones:

  • Los niveles elevados de lípidos no alteran las dimensiones de los vasos coronarios en un estado dilatado.
  • El aumento de la viscosidad sanguínea eleva la resistencia capilar, atenuando la FBC hiperémica.
  • La reserva anormal de CBF en la hiperlipidemia se atribuye al aumento de la viscosidad sanguínea, no al deterioro de la función vascular.