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La meningitis aséptica inducida por infliximab fue inducida por infliximab
Lancet (London, England)
|December 6, 2001
Resumen
La meningitis aséptica ocurrió en un paciente con artritis reumatoide tratado con infliximab, presentándose como dolor muscular severo y meningitis linfocítica transitoria. Esta reacción adversa puede deberse a infliximab.
Área de la Ciencia:
- Neurología Neurología.
- Reumatología Reumatología.
- Inmunología Inmunología.
Sus antecedentes:
- La artritis reumatoide (AR) es una enfermedad autoinmune crónica.
- Infliximab es una terapia biológica dirigida al factor de necrosis tumoral alfa para la AR.
- Las reacciones adversas a los medicamentos requieren una investigación exhaustiva.
Objetivo del estudio:
- Para reportar un caso de meningitis aséptica en un paciente tratado con infliximab.
- Para investigar los mecanismos potenciales detrás de esta reacción adversa.
Principales métodos:
- Informe de caso clínico de un paciente varón de 53 años con artritis reumatoide.
- Análisis del líquido cefalorraquídeo para detectar anticuerpos y marcadores inflamatorios.
- Evaluación de los anticuerpos anti-infliximab y los niveles de factor de necrosis tumoral alfa.
Principales resultados:
- El paciente experimentó dolor muscular severo y meningitis linfocítica transitoria después de las infusiones de infliximab.
- No se detectaron anticuerpos contra núcleos, ADN o neuronas.
- Los anticuerpos funcionales contra el infliximab no fueron inducidos, y los niveles de factor de necrosis tumoral alfa en el líquido espinal no fueron elevados.
Conclusiones:
- La meningitis aséptica fue probablemente una reacción adversa al infliximab.
- La incapacidad de infliximab para penetrar en el sistema nervioso central puede haber contribuido a esta reacción.
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