Video Experimental Relacionado

Updated: Jul 10, 2026

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Published on: December 1, 2011

La infección persistente por el virus del papiloma humano como predictor de la neoplasia intraepitelial cervical

N F Schlecht¹, S Kulaga, J Robitaille

¹Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6. eduardo.franco@mcgill.ca

|January 5, 2002

Resumen

Las infecciones persistentes por el virus del papiloma humano (VPH), especialmente con los tipos 16 o 18 del VPH, aumentan significativamente el riesgo de desarrollar lesiones intraepiteliales escamosas (LIS), un precursor del cáncer de cuello uterino.

Área de la Ciencia:

Oncología Oncología.
Virología Virología.
Epidemiología La epidemiología.

Sus antecedentes:

La infección por el virus del papiloma humano (VPH) es una causa primaria de cáncer de cuello uterino.
La mayor parte de la evidencia que vincula el VPH con el cáncer cervical proviene de estudios retrospectivos.
Existen datos limitados sobre la dinámica de la exposición acumulada o persistente al VPH.

Objetivo del estudio:

Evaluar la asociación entre las infecciones persistentes por VPH y el riesgo de neoplasia cervical.
Evaluar el impacto de tipos específicos de VPH oncogénicos en el desarrollo de la lesión.

Principales métodos:

Un estudio longitudinal se llevó a cabo en São Paulo, Brasil, desde 1993 hasta 2000.
1611 mujeres sin lesiones citológicas iniciales fueron seguidas con pruebas repetidas de VPH y citología.
Las muestras cervicales se analizaron para el VPH y la citología de Papanicolaou cada 4 meses inicialmente, luego dos veces al año.

Principales resultados:

La tasa de incidencia de lesiones intraepiteliales escamosas (SIL) fue significativamente mayor en mujeres con infecciones persistentes por VPH.
Las mujeres con infecciones persistentes del VPH tipo 16 o 18 mostraron un riesgo sustancialmente elevado de SILs.
El riesgo relativo (RR) de SIL incidente fue de 10,19 para las infecciones oncogénicas persistentes por VPH y de 11,67 para SIL de alto grado.

Conclusiones:

Existe una fuerte correlación entre las infecciones persistentes por VPH y la incidencia de SIL.
Las infecciones por los tipos 16 y 18 del VPH demuestran un riesgo particularmente alto de neoplasia cervical.
Los datos longitudinales confirman el papel crítico del VPH persistente en el desarrollo del cáncer cervical.

Más Videos Relacionados

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease

Published on: March 29, 2024

Videos de Conceptos Relacionados

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...