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Enfermedad de Crohn de la enfermedad de Crohn

Fergus Shanahan¹

¹Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland. F.shanahan@ucc.ie

Lancet (London, England)

|January 26, 2002

Resumen

La enfermedad de Crohn involucra linfocitos T y susceptibilidad genética, lo que lleva a una desregulación inmune contra las bacterias intestinales. Comprender las respuestas inmunes ofrece nuevas estrategias terapéuticas para esta compleja enfermedad inflamatoria intestinal.

Área de la Ciencia:

Inmunología Inmunología.
Gastroenterología y Gastroenterología.
Genética La genética.

Sus antecedentes:

La enfermedad de Crohn es un trastorno inmunomediado.
Afecta a las personas genéticamente susceptibles.
Las respuestas inmunes a las bacterias entéricas están desreguladas.

Objetivo del estudio:

Para mejorar la comprensión de la fisiopatología de la enfermedad de Crohn.
Para explorar nuevas opciones terapéuticas.
Para investigar el papel de la regulación inmune.

Principales métodos:

Análisis de las respuestas inmunes mediadas por linfocitos T.
Estudio de la regulación inmunológica de la mucosa.
Investigación de las interacciones de las bacterias entéricas con el huésped.

Principales resultados:

Se observó un desglose en las restricciones regulatorias sobre la inmunidad de la mucosa.
La heterogeneidad de la enfermedad se sugiere con varios defectos subyacentes.
Los tratamientos convencionales se centran en la modificación de la respuesta del huésped.

Conclusiones:

Comprender la reactividad inmune mejora el conocimiento de la enfermedad de Crohn.
La manipulación terapéutica de la flora entérica es una opción viable.
Se justifica una mayor investigación sobre la heterogeneidad de las enfermedades.

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