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Relaciones entre los autores de las directrices de práctica clínica y la industria farmacéutica

Niteesh K Choudhry¹, Henry Thomas Stelfox, Allan S Detsky

¹Mount Sinai Hospital, Room 427, 600 University Ave, Toronto, Ontario, Canada M5G 1X5.

|February 7, 2002

Resumen

Los autores de las directrices de práctica clínica (CPG, por sus siglas en inglés) interactúan con frecuencia con la industria farmacéutica. Este estudio encontró relaciones financieras significativas, destacando la necesidad de divulgación y gestión de conflictos de intereses en el desarrollo de directrices.

Área de la Ciencia:

Investigación médica Investigación médica.
Política de salud pública Política de salud pública.
Ética en la Industria Farmacéutica La ética en la industria farmacéutica La ética en la industria farmacéutica

Sus antecedentes:

El contacto entre el médico y la industria farmacéutica está aumentando.
Los conflictos de interés financieros (FCOI) entre los autores de las directrices de práctica clínica (CPG) no están bien documentados.
Las CPG influyen significativamente en la práctica del médico.

Objetivo del estudio:

Cuantificar el alcance y la naturaleza de las interacciones entre los autores de CPG y la industria farmacéutica.
Evaluar la divulgación de estas relaciones en las directrices publicadas.

Principales métodos:

Encuesta transversal de 192 autores de 44 CPGs (sociedades norteamericanas y europeas, 1991-1999).
100 autores (52%) proporcionaron respuestas utilizables para 37 CPG.
Evaluación de la naturaleza / alcance de las interacciones, las prácticas de divulgación y la influencia percibida en las recomendaciones.

Principales resultados:

El 87% de los autores tenían interacciones con la industria farmacéutica; el 58% recibió apoyo para la investigación, el 38% eran empleados / consultores.
Los autores interactuaron con un promedio de 10,5 empresas.
El 59% tenía relaciones con compañías cuyos medicamentos se discutieron; el 96% de estas relaciones fueron anteriores a la creación de la guía.
Solo 2 GPC revelaron las interacciones financieras individuales del autor.
El 7% creía que su FCOI influyó en las recomendaciones; el 19% creía que el FCOI de los coautores lo hizo.

Conclusiones:

Existe una interacción considerable entre los autores de CPG y la industria farmacéutica.
Destaca la necesidad de una divulgación adecuada de los conflictos de interés financieros.
Hace hincapié en la necesidad de procesos formales para discutir el FCOI antes del desarrollo de CPG.

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