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Placebo y analgesia opiácea: imágenes de una red neuronal compartida

Predrag Petrovic¹, Eija Kalso, Karl Magnus Petersson

¹Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden., Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland.

Science (New York, N.Y.)

|February 9, 2002

Resumen

El placebo y el alivio del dolor por opioides comparten mecanismos cerebrales similares. Ambos activan la corteza cingulada anterior rostral (rACC) e involucran conexiones del tronco encefálico, lo que sugiere una vía neural común para la modulación del dolor.

Área de la Ciencia:

La neurociencia es la neurociencia.
Investigación del dolor Investigación del dolor.
Psicología Psicología Psicología.

Sus antecedentes:

Se cree que la analgesia con placebo involucra redes cognitivas y opioides endógenos.
La corteza cingulada anterior rostral (rACC) y el tronco cerebral son clave en la analgesia opiácea.

Objetivo del estudio:

Para investigar los mecanismos neuronales que subyacen a la analgesia con placebo.
Para determinar si la analgesia con placebo comparte vías neuronales con la analgesia con opioides.

Principales métodos:

La tomografía por emisión de positrones (PET) se utilizó para medir la actividad cerebral.
La actividad cerebral se comparó durante la analgesia opioide, la analgesia con placebo y las condiciones de solo dolor.

Principales resultados:

Tanto la analgesia opioide como la placebo mostraron una mayor actividad en el rACC.
Se observó covarianza entre la actividad del rACC y el tronco cerebral durante la analgesia con opioides y placebo, pero no durante el dolor solo.

Conclusiones:

La analgesia con placebo y opioides involucra mecanismos neuronales relacionados.
El rACC y el tronco cerebral juegan un papel tanto en el alivio del dolor placebo como en el opioide.

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