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Ácidos grasos trans de la membrana celular y el riesgo de paro cardíaco primario
Rozenn N Lemaitre1, Irena B King, Trivellore E Raghunathan
1Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA. rozenl@u.washington.edu
Circulation
|February 13, 2002
Resumen
La ingesta dietética de ácidos grasos trans está relacionada con un mayor riesgo de paro cardíaco primario. Específicamente, los isómeros trans del ácido linoleico mostraron una asociación significativa con un mayor riesgo de paro cardíaco.
Área de la Ciencia:
- Epidemiología cardiovascular y epidemiología cardiovascular.
- Ciencias de la Nutrición Ciencias de la Nutrición
- Investigación de biomarcadores Investigación de biomarcadores.
Sus antecedentes:
- La asociación entre el consumo de ácidos grasos trans y las arritmias potencialmente mortales, incluido el paro cardíaco primario, sigue siendo en gran medida desconocida.
- Comprender los factores de riesgo dietéticos para el paro cardíaco es crucial para las iniciativas de salud pública.
Objetivo del estudio:
- Investigar la relación entre la ingesta de AGT, medida a través de un biomarcador de la membrana de los glóbulos rojos, y el riesgo de paro cardíaco primario.
- Para diferenciar el riesgo asociado con isómeros específicos de ácidos grasos trans.
Principales métodos:
- Se realizó un estudio de casos y controles basado en la población con 179 casos de paro cardíaco fuera del hospital y 285 controles de edad y sexo.
- Los niveles de ácidos grasos trans se evaluaron utilizando muestras de sangre recolectadas en el momento del paro cardíaco o la entrevista.
- Los participantes estaban libres de enfermedad cardíaca preexistente diagnosticada.
Principales resultados:
- Los niveles totales más altos de TFA en las membranas de los glóbulos rojos se asociaron con un aumento modesto en el riesgo de paro cardíaco primario (OR, 1.5; IC del 95%, 1.02.1).
- Los isómeros trans del ácido oleico no mostraron asociación significativa con el riesgo de paro cardíaco (OR, 0,8; IC del 95%, 0,51,2).
- Los niveles elevados de los isómeros trans del ácido linoleico se asociaron fuertemente con un aumento de tres veces en el riesgo de paro cardíaco primario (OR, 3.1; IC del 95%, 1.75.4).
Conclusiones:
- La ingesta dietética de ácidos grasos trans totales está relacionada con un aumento modesto en el riesgo de paro cardíaco primario.
- Los isómeros trans del ácido linoleico, específicamente, demostraron una asociación significativa con un mayor aumento en el riesgo de paro cardíaco.
- Se necesita más investigación para confirmar estos hallazgos y diferenciar entre isómeros específicos de ácidos grasos trans.
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