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Síntesis de beta-lactonas: un catalizador altamente activo y selectivo para la carbonilación de epoxidos
Yutan D Y L Getzler1, Viswanath Mahadevan, Emil B Lobkovsky
1Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853, USA.
Journal of the American Chemical Society
|February 14, 2002
Resumen
Un nuevo catalizador de aluminio-cobalto sintetiza eficientemente las beta-lactonas a partir del monóxido de carbono y los epoxidos. Este nuevo catalizador ofrece altos rendimientos y preserva la estereoquímica en reacciones como la carbonilación del óxido de propileno.
Área de la Ciencia:
- La catálisis de la catálisis.
- Síntesis orgánica La síntesis orgánica.
- Química organometálica Química orgánica de los metales.
Sus antecedentes:
- Las beta-lactonas son valiosos intermediarios sintéticos.
- Se necesitan métodos catalíticos eficientes para la síntesis de beta-lactona a partir de epoxidos y monóxido de carbono.
Objetivo del estudio:
- Informar sobre un nuevo catalizador altamente activo y selectivo para la síntesis de beta-lactona.
- Para investigar la actividad catalítica y la selectividad utilizando varios epóxidos.
Principales métodos:
- Síntesis del catalizador [[[sulfo]]Al[[THF]]2][Co[[CO]]4] a partir de ([[sulfo]]AlCl y NaCo[[CO]]) 4.
- La carbonilación catalítica de epoxidos (óxido de propileno, 1-óxido de buteno, epiclorohidrina, óxido de isobutileno) con monóxido de carbono a 50°C y 880 psi.
- Análisis estereoquímico del producto de la carbonilación del óxido de (R) -propileno.
Principales resultados:
- El catalizador [[[Sálfuro]]Al[[THF]]2][Co[[CO]]4] fue fácilmente preparado.
- Se obtuvieron altos rendimientos de beta-lactonas a partir de varios epóxidos.
- La estereoquímica se mantuvo durante la carbonilación del óxido de (R) -propileno a (R) -beta-butirolactona.
Conclusiones:
- Un nuevo catalizador Al-Co proporciona una ruta eficiente a las beta-lactonas.
- El catalizador demuestra una alta actividad, selectividad y control estereoquímico.
- Este método ofrece una herramienta valiosa para la síntesis de beta-lactonas funcionalizadas.
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